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Which of the following phenomena could potentially underlie the woman’s health problem?

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A 51-year-old woman has been experiencing signs and symptoms of perimenopause and has sought help from her nurse practitioner. Doctors have confirmed a deficiency in estrogen levels as a contributing factor. Which of the following phenomena could potentially underlie the woman’s health problem?
Sufficient synthesis of estrogen but inadequate vesicle-mediated release
Inadequate synthesis in the rough endoplasmic reticulum of her ovarian cells
Insufficient estrogen production within the smooth endoplasmic reticulum of the relevant cells
A lack of prohormone precursors needed for estrogen synthesis and release

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